1,4-Dioxane

CAS 123-91-1 C₄H₈O₂ MW 88.1000 Danger
NIOSH Potential Occupational Carcinogen
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Skull and Crossbones Skull and Crossbones
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Health Hazard Health Hazard
Emergency: 911 | Poison Control: 1-800-222-1222

Hazard Statements

CodeStatementHazard Class
H225 Highly Flammable liquid and vapor Flammable liquids
H313 May be harmful in contact with skin Acute toxicity, dermal
H315 Causes skin irritation Skin corrosion/irritation
H319 Causes serious eye irritation Serious eye damage/eye irritation
H331 Toxic if inhaled Acute toxicity, inhalation
H335 May cause respiratory irritation Specific target organ toxicity, single exposure; Respiratory tract irritation
H336 May cause drowsiness or dizziness Specific target organ toxicity, single exposure; Narcotic effects
H351 Suspected of causing cancer Carcinogenicity
H370 Causes damage to organs Specific target organ toxicity, single exposure
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure
H373 May causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure

Precautionary Statements

CodeStatement
P203 Obtain, read and follow all safety instructions before use.
P210 Keep away from heat, hot surface, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/.../] equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P260 Do not breathe dust/fume/gas/mist/vapors/spray.
P261 Avoid breathing dust/fume/gas/mist/vapors/spray.
P264 Wash hands [and ...] thoroughly after handling.
P264+P265 Wash hands [and ...] thoroughly after handling. Do not touch eyes.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P302+P317 (Deleted) IF ON SKIN: Get medical help.
P302+P352 IF ON SKIN: wash with plenty of water/...
P303+P361+P353 IF ON SKIN (or hair): Take off Immediately all contaminated clothing. Rinse SKIN with water [or shower].
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P308+P316 IF exposed or concerned: Get emergency medical help immediately.
P316 Get emergency medical help immediately.
P318 if exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
P321 Specific treatment (see information on this label and safety datasheet)).
P332+P317 If skin irritation occurs: Get medical help.
P337+P317 If eye irritation persists: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P370+P378 In case of fire: Use ... to extinguish.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container to ...

Exposure Limits

OSHA PEL100 ppm
NIOSH RELCeiling: 1 ppm
NIOSH IDLH500 ppm
Skin NotationYes — can be absorbed through skin

Physical Properties

Colorless liquid or solid (below 53°F) with a mild, ether-like odor.

Boiling Point214°F
Flash Point55°F
Vapor Pressure29 mmHg
Specific Gravity1.03

NFPA 704 Diamond

3
2
1
Health Fire Reactivity

Target Organs

Liver

potential for cancer; liver and kidney effects; liver, lung, and nasal cavity tumors in animals

Synonyms

diethylene ether; dioxan; p-dioxane; 1,4-diethyleneoxide

Data Sources

Disclaimer: This information is compiled from public regulatory databases for reference only. It does not replace the manufacturer's Safety Data Sheet (SDS). Always consult the official SDS for your specific product before handling chemicals.

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